Publications
Featured Publications
The evolutionary trajectory of glioblastoma (GBM) is a multifaceted biological process that extends beyond genetic alterations alone. Here, we perform an integrative proteogenomic analysis of 123 longitudinal glioblastoma pairs and identify a highly proliferative cellular state at diagnosis and replacement by activation of neuronal transition and synaptogenic pathways in recurrent tumors. Proteomic and phosphoproteomic analyses reveal that the molecular transition to neuronal state at recurrence is marked by post-translational activation of the wingless-related integration site (WNT)/ planar cell polarity (PCP) signaling pathway and BRAF protein kinase. Consistently, multi-omic analysis of patient-derived xenograft (PDX) models mirror similar patterns of evolutionary trajectory. Inhibition of B-raf proto-oncogene (BRAF) kinase impairs both neuronal transition and migration capability of recurrent tumor cells, phenotypic hallmarks of post-therapy progression. Combinatorial treatment of temozolomide (TMZ) with BRAF inhibitor, vemurafenib, significantly extends the survival of PDX models. This study provides comprehensive insights into the biological mechanisms of glioblastoma evolution and treatment resistance, highlighting promising therapeutic strategies for clinical intervention.
The fundamental principle of precision oncology is centralized on identification of therapeutically exploitable targets that provides individual cancer patients an opportunity to make informed decisions on a personalized level. To facilitate and adopt such concepts within clinical practice, we have initiated a nation-wide, multi-institutional precision oncology screening program to examine and enroll patients into the most appropriate clinical trial based on their unique molecular properties. To determine prevalence of essential major driver mutations and to explore their dynamic associations at both single molecular and pathway levels, we first present a comprehensive overview on the genomic properties of East Asian cancer patients. We further delineated the extent of genomic diversity as well as clinical utility between patients from western and eastern cultures at the pan-cancer and single tumor entity levels.
Outcomes of anticancer therapy vary dramatically among patients due to diverse genetic and molecular backgrounds, highlighting extensive intertumoral heterogeneity. The fundamental tenet of precision oncology defines molecular characterization of tumors to guide optimal patient-tailored therapy. Towards this goal, we have established a compilation of pharmacological landscapes of 462 patient-derived tumor cells (PDCs) across 14 cancer types, together with genomic and transcriptomic profiling in 385 of these tumors. Compared with the traditional long-term cultured cancer cell line models, PDCs recapitulate the molecular properties and biology of the diseases more precisely. Here, we provide insights into dynamic pharmacogenomic associations, including molecular determinants that elicit therapeutic resistance to EGFR inhibitors, and the potential repurposing of ibrutinib (currently used in hematological malignancies) for EGFR-specific therapy in gliomas. Lastly, we present a potential implementation of PDC-derived drug sensitivities for the prediction of clinical response to targeted therapeutics using retrospective clinical studies.
Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies. However, this proposition is complicated by spatial and temporal heterogeneity. Here we study genomic and expression profiles across 127 multisector or longitudinal specimens from 52 individuals with glioblastoma (GBM). Using bulk and single-cell data, we find that samples from the same tumor mass share genomic and expression signatures, whereas geographically separated, multifocal tumors and/or long-term recurrent tumors are seeded from different clones. Chemical screening of patient-derived glioma cells (PDCs) shows that therapeutic response is associated with genetic similarity, and multifocal tumors that are enriched with PIK3CA mutations have a heterogeneous drug-response pattern. We show that targeting truncal events is more efficacious than targeting private events in reducing the tumor burden. In summary, this work demonstrates that evolutionary inference from integrated genomic analysis in multisector biopsies can inform targeted therapeutic interventions for patients with GBM.
*As first or corresponding author (Members of the Sa Lab are underlined and boldfaced)
2024
Kyung-Hee Kim*, Simona Migliozzi*, Harim Koo*, Jun-Hee Hong*, Seung Min Park, Sooheon Kim, Hyung Joon Kwon, Seokjun Ha, Luciano Garofano, Young Taek Oh, Fulvio D'Angelo, Chan Il Kim, Seongsoo Kim, Ji Yoon Lee, Jiwon Kim, Jisoo Hong, Eun-Hae Jang, Bertrand Mathon, Anna-Luisa Di Stefano, Franck Bielle, Alice Laurenge, Alexey I Nesvizhskii, Eun-Mi Hur, Jinlong Yin, Bingyang Shi, Youngwook Kim, Kyung-Sub Moon, Jeong Taik Kwon, Shin Heon Lee, Seung Hoon Lee, Ho Shin Gwak, Anna Lasorella, Heon Yoo, Marc Sanson*, Jason K Sa*, Chul-Kee Park*, Do-Hyun Nam*, Antonio Iavarone*, Jong Bae Park*
Cancer Cell, Epub ahead of print, 2024 (Impact Factor: 50.3)
2023
Yoonhee Nam*, Harim Koo*, Yingxi Yang*, Sang Shin, Zhihan Zhu, Donggeon Kim, Hee Jin Cho, Quanhua Mu, Seung Won Choi, Jason K Sa, Yun Jee Seo, Yejin Kim, Kyoungmin Lee, Jeong-Woo Oh, Yong-Jun Kwon, Woong-Yang Park, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Chul-Kee Park, Hye Won Lee, Yeup Yoon, Jiguang Wang
Sang-Yun Lee , Hyun Ju Hwang, You Jin Song, Dayoung Lee, Bosung Ku, Jason K Sa*, Dong Woo Lee*
Quanhua Mu, Ruichao Chai, Bo Pang, Yingxi Yang, Hanjie Liu, Zheng Zhao, Zhaoshi Bao, Dong Song, Zhihan Zhu, Mengli Yan, Biaobin Jiang, Zongchao Mo, Jihong Tang, Jason K Sa, Hee Jin Cho, Yuzhou Chang, Kaitlin Hao Yi Chan, Danson Shek Chun Loi, Sindy Sing Ting Tam, Aden Ka Yin Chan, Angela Ruohao Wu, Zhaoqi Liu, Wai Sang Poon, Ho Keung Ng, Danny Tat Ming Chan, Antonio Iavarone, Do-Hyun Nam, Tao Jiang, Jiguang Wang
Science Translational Medicine, 15(716):eadh4181, 2023 (Impact Factor: 17.1)
Dasom Kim, Dongwha Min, Joohee Kim, Min Jung Kim, Yerim Seo, Byung Hwa Jung, Seung-Hae Kwon, Hyunju Ro, Seoee Lee, Jason K Sa, Ji-Yun Lee
Journal of Experimental & Clinical Cancer Research, 42(1):338, 2023 (Impact Factor: 11.3)
Jae Ryoung Hwang, Young-Jae Cho, Ji-Yoon Ryu, Ju-Yeon Choi, Jung-Joo Choi, Jason K Sa, Hyun-Soo Kim, Jeong-Won Lee
Biomedicine & Pharmacotherapy, Epub ahead of print, 2023 (Impact Factor: 7.5)
Hye-Min Jeon, Yong Jae Shin, Jaehyun Lee, Nakho Chang, Dong-Hun Woo, Won Jun Lee, Dayna Nguyen, Wonyoung Kang, Hee Jin Cho, Heekyoung Yang, Jin-Ku Lee, Jason K Sa, Yeri Lee, Dong Geon Kim, Benjamin W Purow, Yeup Yoon, Do-Hyun Nam, Jeongwu Lee
Jihye Kim, Nakho Chang, Yunki Kim, Jaehyun Lee, Daeseok Oh, Jaeyoung Choi, Onyou Kim, Sujin Kim, Myongho Choi, Junyeob Lee, Junghwa Lee, Jungyul Kim, Minji Cho, Minsu Kim, Kwanghwan Lee, Dukhyun Hwang, Jason K Sa, Sungjin Park, Seungjae Baek, Daeseong Im
Hye-Min Jeon, Young Taek Oh, Yong Jae Shin, Nakho Chang, Donggeun Kim, Donghun Woo, Yoon Yeup, Kyeung Min Joo, Heejin Jo, Heekyoung Yang, Jin-Ku Lee, Wonyoung Kang, Jason Sa, Won Jun Lee, James Hale, Justin D Lathia, Benjamin Purow, Myung Jin Park, Jong Bae Park, Do-Hyun Nam, Jeongwu Lee
2022
Kyong Hwa Park, Jung Yoon Choi, Ah-Reum Lim, Ju Won Kim, Yoon Ji Choi, Soohyeon Lee, Jae Sook Song, Hee-Joon Chung, Byunghyun Jang, Dayoung Yoon, Sukwon Kim, Jason K Sa*, Yeul Hong Kim*
Hyunho Kim*, Jason K Sa*, Jaehoon Kim , Hee Jin Cho , Hyun Jeong Oh, Dong-Hee Choi, Seok-Hyeon Kang, Da Eun Jeong, Do-Hyun Nam, Hakho Lee, Hye Won Lee, Seok Chung
Advanced Science, 9(22):e2201785, 2022 (Impact Factor: 15.66)
Jung Yong Hong*, Hee Jin Cho*, Jason K Sa*, Xiaoqiao Liu*, Sang Yun Ha*, Taehyang Lee, Hajung Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Hee Chul Park, Tae Wook Kang, Hyunchul Rhim, Su Jin Lee, Razvan Cristescu, Jeeyun Lee, Yong Han Paik , Ho Yeong Lim
Jason K Sa*, Jihye Kim*, Sokbom Kang, Sang Wun Kim, Taejong Song, Seung-Hyuk Shim, Min Chul Choi, Jae Hong No, Jae-Yun Song, Deokhoon Kim, Yong-Man Kim, Jae-Hoon Kim, Jeong-Won Lee
International Journal of Cancer, 151(7):1086-1097, 2022 (Impact Factor: 7.4)
Jung-In Shim, Ji-Yoon Ryu, Soo Young Jeong, Young-Jae Cho, Jung-Joo Choi, Jae Ryoung Hwang, Ju-Yeon Choi, Jason K Sa, Jeong-Won Lee
Gynecologic Oncology, 165(2):270-280, 2022 (Impact Factor: 5.48)
Hyungsin Kim, Jeongsoo Kim, Jason K Sa, Byung-Kyu Ryu, Kyung-Jae Park, Jiyoung Kim, Hyojeong Ha, Yejin Park, Min Hwa Shin, Jungwon Kim, Hyemin Lee, Daham Kim, Kyunghye Lee, Byunghyun Jang, Kyung-Mi Lee, Shin-Hyuk Kang
Biomedicine & Pharmacotherapy, 154:113553, 2022 (Impact Factor: 6.53)
Na Kyung Lee, Su Hyeon Myeong, Jung Won Hwang, Jason K Sa, Hyo Jin Son, Hee Jin Kim, Hyemin Jang, Jong Wook Chang, Duk L Na
Biomedicines, 10(8):1882, 2022 (Impact Factor: 4.72)
2021
Seung Tae Kim*, Jason K Sa*, Sung Yong Oh*, Kyung Kim, Jung Yong Hong, Won Ki Kang, Kyoung-Mee Kim, Jeeyun Lee
Jun-Hee Hong*, Sangjo Kang*, Jason K Sa*, Gunwoo Park*, Young Taek Oh, Tae Hoon Kim, Jinlong Yin, Sung Soo Kim, Fulvio D'Angelo, Harim Koo, Yeonhee You, Saewhan Park, Hyung Joon Kwon, Chan Il Kim, Haseo Ryu, Weiwei Lin, Eun Jung Park, Youn-Jae Kim, Myung-Jin Park, Hyunggee Kim, Mi-Suk Kim, Seok Chung, Chul-Kee Park, Sung-Hye Park, Yun Hee Kang, Jong Heon Kim, Hideyuki Saya, Ichiro Nakano, Ho-Shin Gwak, Heon Yoo, Jeongwu Lee, Eun-Mi Hur, Bingyang Shi, Do-Hyun Nam, Antonio Iavarone, Seung-Hoon Lee, Jong Bae Park
Hyun Nam*, In-Hee Lee*, Jason K Sa*, Sung Soo Kim*, Hee-Jang Pyeon, Kee Hang Lee, Kyunghoon Lee, Sun-Ho Lee, Kyeung Min Joo
Stem Cell Reviews and Reports, 18(1):241-257, 2021 (Impact Factor: 5.74)
Minsuk Kwon, Minae An, Samuel J Klempner, Hyuk Lee, Kyoung-Mee Kim, Jason K Sa, Hee Jin Cho, Jung Yong Hong, Taehyang Lee, Yang Won Min, Tae Jun Kim, Byung-Hoon Min, Woong-Yang Park, Won Ki Kang, Kyu-Tae Kim, Seung Tae Kim, Jeeyun Lee
Cancer Discovery, 11(9):2168-2185, 2021 (Impact Factor: 39.4)
Seung Won Choi, Yeri Lee, Kayoung Shin, Harim Koo, Donggeon Kim, Jason K Sa, Hee Jin Cho, Hye-Mi Shin, Se Jeong Lee, Hyunho Kim, Seok Chung, Jihye Shin, Cheolju Lee, Do-Hyun Nam
2020
Jason K Sa*, Jung Yong Hong*, In-Kyoung Lee, Ju-Sun Kim, Moon-Hee Sim, Ha Jung Kim, Ji Yeong An, Tae Sung Sohn, Joon Ho Lee, Jae Moon Bae, Sung Kim, Kyoung-Mee Kim, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Nam-Gu Her, Yeri Lee, Hee Jin Cho, Yong Jae Shin, Misuk Kim, Harim Koo, Mirinae Kim, Yun Jee Seo, Ja Yeon Kim, Min-Gew Choi, Do-Hyun Nam, Jeeyun Lee
Jason K Sa*, Nakho Chang*, Hye Won Lee*, Hee Jin Cho*, Michele Ceccarelli*, Luigi Cerulo, Jinlong Yin, Sung Soo Kim, Francesca P Caruso, Mijeong Lee, Donggeon Kim, Young Taek Oh, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Hye-Jin Kim, Da Eun Jeong, Hye-Mi Kim, Hyunho Kim, Seok Chung, Hyun Goo Woo, Jeongwu Lee, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Jinho Kim, Woong-Yang Park, Qianghu Wang, Erik P Sulman, Amy B Heimberger, Michael Lim, Jong Bae Park, Antonio Iavarone , Roel G W Verhaak, Do-Hyun Nam
Hye Won Lee*, Jason K Sa*, Antonio Gualberto, Catherine Scholz, Hyun Hwan Sung, Byong Chang Jeong, Han Yong Choi, Ghee Young Kwon, Se Hoon Park
Clinical Cancer Research, 26(19):5113-5119, 2020 (Impact Factor: 12.53)
Harim Koo, Seung Won Choi, Hee Jin Cho, In-Hee Lee, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Jung-Won Choi, Jason K Sa*, Do-Hyun Nam*
Cancer Medicine, 9(19):7352-7359, 2020 (Impact Factor: 4.45)
Hyemi Shin*, Jason K Sa*, Joon Seol Bae*, Harim Koo, Seonwhee Jin, Hee Jin Cho, Seung Won Choi, Jong Min Kyoung, Ja Yeon Kim, Yun Jee Seo, Je-Gun Joung, Nayoung K D Kim, Dae-Soon Son, Jongsuk Chung, Taeseob Lee, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Yeon-Lim Suh, Woong-Yang Park, Do-Hyun Nam
Cancer Research and Treatment, 52(1):41-50, 2020 (Impact Factor: 4.68)
Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G W Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, Massimo Squatrito
Nature Communications, 11(1):3883, 2020 (Impact Factor: 14.92)
Jinlong Yin, Sung Soo Kim, Eunji Choi, Young Taek Oh, Weiwei Lin, Tae-Hoon Kim, Jason K Sa, Jun Hee Hong, Se Hwan Park, Hyung Joon Kwon, Xiong Jin, Yeonhee You, Ji Hye Kim, Hyunggee Kim, Jaekyoung Son, Jeongwu Lee, Do-Hyun Nam, Kui Son Choi, Bingyang Shi, Ho-Shin Gwak, Heon Yoo, Antonio Iavarone, Jong Heon Kim, Jong Bae Park
Nature Communications, 11(1):2978, 2020 (Impact Factor: 14.92)
Sejin Oh, Jeonghun Yeom, Hee Jin Cho, Ju-Hwa Kim, Seon-Jin Yoon, Hakhyun Kim, Jason K Sa, Shinyeong Ju, Hwanho Lee, Myung Joon Oh, Wonyeop Lee, Yumi Kwon, Honglan Li, Seunghyuk Choi, Jang Hee Han, Jong Hee Chang, Eunsuk Choi, Jayeon Kim, Nam-Gu Her, Se Hoon Kim, Seok-Gu Kang, Eunok Paek, Do-Hyun Nam, Cheolju Lee, Hyun Seok Kim
Nature Communications, 11(1):3288, 2020 (Impact Factor: 14.92)
Seung Won Choi, Hwan-Ho Cho, Harim Koo, Kyung Rae Cho, Karl-Heinz Nenning, Georg Langs, Julia Furtner, Bernhard Baumann, Adelheid Woehrer, Hee Jin Cho, Jason K Sa, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Do-Hyun Nam, Hyunjin Park
E Sun Paik, Tae-Hyun Kim, Young Jae Cho, Jiyoon Ryu, Jung-Joo Choi, Yoo-Young Lee, Tae-Joong Kim, Chel-Hun Choi, Woo Young Kim, Jason K Sa, Jin-Ku Lee, Byoung-Gie Kim, Duk-Soo Bae, Hee Dong Han, Hyung Jun Ahn, Jeong-Won Lee
2019
Jason K Sa*, Jae Ryoung Hwang*, Young-Jae Cho*, Ji-Yoon Ryu, Jung-Joo Choi, Soo Young Jeong, Jihye Kim, Myeong Seon Kim, E Sun Paik, Yoo-Young Lee, Chel Hun Choi, Tae-Joong Kim, Byoung-Gie Kim, Duk-Soo Bae, Yeri Lee, Nam-Gu Her, Yong Jae Shin, Hee Jin Cho, Ja Yeon Kim, Yun Jee Seo, Harim Koo, Jeong-Woo Oh, Taebum Lee, Hyun-Soo Kim, Sang Yong Song, Joon Seol Bae, Woong-Yang Park, Hee Dong Han, Hyung Jun Ahn, Anil K Sood, Raul Rabadan, Jin-Ku Lee, Do-Hyun Nam, Jeong-Won Lee
Jason K Sa*, Sung Heon Kim*, Jin-Ku Lee, Hee Jin Cho, Yong Jae Shin, Hyemi Shin, Harim Koo, Donggeon Kim, Mijeong Lee, Wonyoung Kang, Sung Hee Hong, Jung Yong Kim, Young-Whan Park, Seong-Won Song, Song-Jae Lee, Kyeung Min Joo, Do-Hyun Nam
Yong Jae Shin*, Jason K Sa*, Yeri Lee, Donggeon Kim, Nakho Chang, Hee Jin Cho, Miseol Son, Michael Y T Oh, Kayoung Shin, Jin-Ku Lee, Jiwon Park, Yoon Kyung Jo, Misuk Kim, Patrick J Paddison, Vinay Tergaonkar, Jeongwu Lee, Do-Hyun Nam
Journal of Experimental Medicine, 216(5):1120-1134, 2019 (Impact Factor: 14.31)
Sung Hee Lim*, Jason K Sa*, Dong Woo Lee*, Jusun Kim, Seung Tae Kim, Se Hoon Park, Bosung Ku, Joon Oh Park, Young Suk Park, Hoyeong Lim, Won Ki Kang, Do-Hyun Nam, Jeeyun Lee
Jason K Sa*, Seung Won Choi*, Junfei Zhao, Yeri Lee, Jing Zhang, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Antonio Iavarone, Raul Rabadan, Do-Hyun Nam
International Journal of Cancer, 144(12):3023-3030, 2019 (Impact Factor: 7.4)
Hee-Young Jeon, Seok Won Ham, Jun-Kyum Kim, Xiong Jin, Seon Yong Lee, Yong Jae Shin, Chang-Yong Choi, Jason K Sa, Se Hoon Kim, Taehoon Chun, Xun Jin, Do-Hyun Nam, Hyunggee Kim
Cell Death and Differentiation, 26(10):2139-2156, 2019 (Impact Factor: 15.83)
Floris P Barthel, Kevin C Johnson, Frederick S Varn, Anzhela D Moskalik, Georgette Tanner, Emre Kocakavuk, Kevin J Anderson, Olajide Abiola, Kenneth Aldape, Kristin D Alfaro, Donat Alpar, Samirkumar B Amin, David M Ashley, Pratiti Bandopadhayay, Jill S Barnholtz-Sloan, Rameen Beroukhim, Christoph Bock, Priscilla K Brastianos, Daniel J Brat, Andrew R Brodbelt, Alexander F Bruns, Ketan R Bulsara, Aruna Chakrabarty, Arnab Chakravarti, Jeffrey H Chuang, Elizabeth B Claus, Elizabeth J Cochran, Jennifer Connelly, Joseph F Costello, Gaetano Finocchiaro, Michael N Fletcher, Pim J French, Hui K Gan, Mark R Gilbert, Peter V Gould, Matthew R Grimmer, Antonio Iavarone, Azzam Ismail, Michael D Jenkinson, Mustafa Khasraw, Hoon Kim, Mathilde C M Kouwenhoven, Peter S LaViolette, Meihong Li, Peter Lichter, Keith L Ligon, Allison K Lowman, Tathiane M Malta, Tali Mazor, Kerrie L McDonald, Annette M Molinaro, Do-Hyun Nam, Naema Nayyar, Ho Keung Ng, Chew Yee Ngan, Simone P Niclou, Johanna M Niers, Houtan Noushmehr, Javad Noorbakhsh, D Ryan Ormond, Chul-Kee Park, Laila M Poisson, Raul Rabadan, Bernhard Radlwimmer, Ganesh Rao, Guido Reifenberger, Jason K Sa, Michael Schuster, Brian L Shaw, Susan C Short, Peter A Sillevis Smitt, Andrew E Sloan, Marion Smits, Hiromichi Suzuki, Ghazaleh Tabatabai, Erwin G Van Meir, Colin Watts, Michael Weller, Pieter Wesseling, Bart A Westerman, Georg Widhalm, Adelheid Woehrer, W K Alfred Yung, Gelareh Zadeh, Jason T Huse, John F De Groot, Lucy F Stead, Roel G W Verhaak, GLASS Consortium
Hee Jin Cho, Junfei Zhao, Sang Won Jung, Erik Ladewig, Doo-Sik Kong, Yeon-Lim Suh, Yeri Lee, Donggeon Kim, Sun Hee Ahn, Mykola Bordyuh, Hyun Ju Kang, Jason K Sa, Yun Jee Seo, Sung Tae Kim, Do Hoon Lim, Yun-Sik Dho, Jung-Il Lee, Ho Jun Seol, Jung Won Choi, Woong-Yang Park, Chul-Kee Park, Raul Rabadan, Do-Hyun Nam
Jing Zhang, Francesca P Caruso, Jason K Sa, Sune Justesen, Do-Hyun Nam, Peter Sims, Michele Ceccarelli, Anna Lasorella, Antonio Iavarone
2018
Jin-Ku Lee*, Zhaoqi Liu*, Jason K Sa*, Sang Shin*, Jiguang Wang*, Mykola Bordyuh, Hee Jin Cho, Oliver Elliott, Timothy Chu, Seung Won Choi, Daniel I S Rosenbloom, In-Hee Lee, Yong Jae Shin, Hyun Ju Kang, Donggeon Kim, Sun Young Kim, Moon-Hee Sim, Jusun Kim, Taehyang Lee, Yun Jee Seo, Hyemi Shin, Mijeong Lee, Sung Heon Kim, Yong-Jun Kwon, Jeong-Woo Oh, Minsuk Song, Misuk Kim, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Seung Tae Kim, Joon Oh Park, Kyoung-Mee Kim, Sang-Yong Song, Jeong-Won Lee, Hee-Cheol Kim, Jeong Eon Lee, Min Gew Choi, Sung Wook Seo, Young Mog Shim, Jae Ill Zo, Byong Chang Jeong, Yeup Yoon, Gyu Ha Ryu, Nayoung K D Kim, Joon Seol Bae, Woong-Yang Park, Jeongwu Lee, Roel G W Verhaak, Antonio Iavarone, Jeeyun Lee, Raul Rabadan, Do-Hyun Nam
Nature Genetics, 50(10):1399-1411, 2018 (Impact Factor: 38.33)
Huimin Hu, Quanhua Mu, Zhaoshi Bao, Yiyun Chen, Yanwei Liu, Jing Chen, Kuanyu Wang, Zheng Wang, Yoonhee Nam, Biaobin Jiang, Jason K Sa, Hee-Jin Cho, Nam-Gu Her, Chuanbao Zhang, Zheng Zhao, Ying Zhang, Fan Zeng, Fan Wu, Xun Kang, Yuqing Liu, Zenghui Qian, Zhiliang Wang, Ruoyu Huang, Qiangwei Wang, Wei Zhang, Xiaoguang Qiu, Wenbin Li, Do-Hyun Nam, Xiaolong Fan, Jiguang Wang, Tao Jiang
J Matthew Barnes, Shelly Kaushik, Russell O Bainer, Jason K Sa, Elliot C Woods, FuiBoon Kai, Laralynne Przybyla, Mijeong Lee, Hye Won Lee, Jason C Tung, Ori Maller, Alexander S Barrett, Kan V Lu, Jonathon N Lakins, Kirk C Hansen, Kirsten Obernier, Arturo Alvarez-Buylla, Gabriele Bergers, Joanna J Phillips, Do-Hyun Nam, Carolyn R Bertozzi, Valerie M Weaver
Nature Cell Biology, 20(10):1203-1214, 2018 (Impact Factor: 28.82)
Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, Hoon Kim, Mathilde C M Kouwenhoven, Kerrie L McDonald, Hrvoje Miletic, Do-Hyun Nam, Ho Keung Ng, Simone P Niclou, Houtan Noushmehr, D Ryan Ormond, Laila M Poisson, Guido Reifenberger, Federico Roncaroli, Jason K Sa, Peter A E Sillevis Smitt, Marion Smits, Camila F Souza, Ghazaleh Tabatabai, Erwin G Van Meir, Roel G W Verhaak, Colin Watts, Pieter Wesseling, Adelheid Woehrer, W K Alfred Yung, Christine Jungk, Ann-Christin Hau, Eric van Dyck, Bart A Westerman, Julia Yin, Olajide Abiola, Nikolaj Zeps, Sean Grimmond, Michael Buckland, Mustafa Khasraw, Erik P Sulman, Andrea M Muscat, Lucy Stead, GLASS Consortium
Seung Won Choi, Hyemi Shin, Jason K Sa, Hee Jin Cho, Harim Koo, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam
Jaehyun Lee, Yong Jae Shin, Kyoungmin Lee, Hee Jin Cho, Jason K Sa, Sang-Yun Lee, Seok-Hyung Kim, Jeongwu Lee, Yeup Yoon, Do-Hyun Nam
Cancer Research and Treatment, 50(3):1009-1022, 2018 (Impact Factor: 4.68)
Jongmin Sim, Do-Hyun Nam, Yuil Kim, In-Hee Lee, Jung Won Choi, Jason K Sa, Yeon-Lim Suh
Jaehyun Lee, Donggeon Kim, Eunju Son, Su-Ji Yoo, Jason K Sa, Yong Jae Shin, Yeup Yoon, Do-Hyun Nam
Anticancer Research, 38(5):2803-2810, 2018 (Impact Factor: 2.48)
2017
Jin-Ku Lee*, Jiguang Wang*, Jason K Sa*, Erik Ladewig*, Hae-Ock Lee, In-Hee Lee, Hyun Ju Kang, Daniel S Rosenbloom, Pablo G Camara, Zhaoqi Liu, Patrick van Nieuwenhuizen, Sang Won Jung, Seung Won Choi, Junhyung Kim, Andrew Chen, Kyu-Tae Kim, Sang Shin, Yun Jee Seo, Jin-Mi Oh, Yong Jae Shin, Chul-Kee Park, Doo-Sik Kong, Ho Jun Seol, Andrew Blumberg, Jung-Il Lee, Antonio Iavarone, Woong-Yang Park, Raul Rabadan, Do-Hyun Nam
Jason K Sa, In-Hee Lee, Sang Duk Hong, Doo-Sik Kong, Do-Hyun Nam
Jinlong Yin, Young Taek Oh, Jeong-Yub Kim, Sung Soo Kim, Eunji Choi, Tae Hoon Kim, Jun Hee Hong, Nakho Chang, Hee Jin Cho, Jason K Sa, Jeong Cheol Kim, Hyung Joon Kwon, Saewhan Park, Weiwei Lin, Ichiro Nakano, Ho-Shin Gwak, Heon Yoo, Seung-Hoon Lee, Jeongwu Lee, Jong Heon Kim, Soo-Youl Kim, Do-Hyun Nam, Myung-Jin Park, Jong Bae Park
Cancer Research, 77(18):4973-4984, 2017 (Impact Factor: 12.7)
Hyunkyu Park, Donggeon Kim, Eunmi Kim, Jason K Sa, Hee Won Lee, Suji Yu, Jiwon Oh, Seok-Hyung Kim, Yeup Yoon, Do-Hyun Nam
International Journal of Molecular Sciences, 18(9):1968, 2017 (Impact Factor: 4.56)
Hyunkyu Park, Donggeon Kim, Eunju Son, Sunhwa Shin, Jason K Sa, Seok-Hyung Kim, Yeup Yoon, Do-Hyun Nam
Biochemical and Biophysical Research Communications, 494(1-2):409-415, 2017 (Impact Factor: 3.58)
2016
Yu Jin Cho, Wonyoung Kang, Sung Heon Kim, Jason K Sa, Nayoung Kim, Patrick J Paddison, Misuk Kim, Kyeung Min Joo, Young-Il Hwang, Do-Hyun Nam
International Journal of Oncology, 48(3):1053-62, 2016 (Impact Factor: 5.65)
Dong Geon Kim, Kang Ho Kim, Yun Jee Seo, Heekyoung Yang, Eric G Marcusson, Eunju Son, Kyoungmin Lee, Jason K Sa, Hye Won Lee, Do-Hyun Nam
2015
Jason K Sa*, Yeup Yoon*, Misuk Kim*, Yeonghwan Kim*, Hee Jin Cho, Jin-Ku Lee, Gi-Soo Kim, Suji Han, Woon Jin Kim, Yong Jae Shin, Kyeung Min Joo, Patrick J Paddison, Tohru Ishitani, Jeongwu Lee, Do-Hyun Nam